Thyrostimulin, but Not Thyroid-stimulating Hormone, Acts as a Paracrine Regulator to Activate Thyroid-stimulating Hormone Receptor in the Mammalian Ovary
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چکیده
THYROSTIMULIN, BUT NOT THYROID-STIMULATING HORMONE, ACTS AS A PARACRINE REGULATOR TO ACTIVATE THYROID-STIMULATING HORMONE RECEPTOR IN THE MAMMALIAN OVARY Su-Chin Sun, Pei-Jen Hsu, Fang-Ju Wu, Sheng-Hsiang Li, Chung-Hao Lu and Ching-Wei Luo Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei, Taiwan. Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan Running head: Thyrostimulin-TSHR signaling in the ovary *Corresponding author: Ching-Wei Luo, Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, 155 Li-Nong Street, Section 2, Shihpai, Taipei 112, Taiwan. Tel: 886-2-28267185; Fax: 886-2-28202449; Email: [email protected]
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Thyrostimulin, a heterodimer of two new human glycoprotein hormone subunits, activates the thyroid-stimulating hormone receptor.
Human thyrotropin (TSH), luteotropin (LH), follitropin (FSH), and chorionic gonadotropin are members of the heterodimeric glycoprotein hormone family. The common alpha subunit forms noncovalent heterodimers with different beta subunits. Two novel human glycoprotein hormonelike genes, alpha2 (A2) and beta5 (B5), recently have been identified. Using a yeast two-hybrid assay, the two subunits were...
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